Self-guided Sightseeing Tour #1 in Santo Domingo, Dominican Republic

The Museo de las Casas Reales is one of the important cultural monuments built during the colonial era in Hispaniola, now the Dominican Republic. It is located in the Colonial district of Santo Domingo.

Wikipedia: Museo de las Casas Reales (EN)

The Hospital San Nicolás de Bari is a preserved hospital ruin, and it was recognized by UNESCO for being the oldest hospital built in the Americas. Construction began in 1503 in Santo Domingo, Dominican Republic, at the behest of governor Nicolás de Ovando. This grand project was in keeping with the desire to emulate European princely courts, and looked to Renaissance Italy for inspiration. At the time of its completion, the wards could accommodate up to 70 patients, comparable to the most advanced churches of Rome. It is likely that the model for the Hospital de San Nicolás was the large Ospedale di Santo Spirito in Sassia in Rome. The complex forms part of the Colonial Zone of Santo Domingo World Heritage Site.

Wikipedia: Hospital San Nicolás de Bari (EN)

The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the oldest existing cathedral in the Americas, begun in 1504 and was completed in 1550, and the second constructed, after the Garðar Cathedral Ruins in Greenland. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first diocese and the oldest cathedral established in the New World in the post-Columbus era.

Wikipedia: Cathedral of Santo Domingo (EN)

The Ozama Fortress, also formerly known as the city wall's Homage tower, is one of the surviving sections of the Walls of Santo Domingo, which is recognized by UNESCO as being the oldest military construction of European origin in the Americas. It was built between 1502–1508 by the Spanish at the entrance to Santo Domingo's Ciudad Colonial, Dominican Republic, and overlooking the Ozama River. Named after this river, the castle, also referred to as "La Fortaleza" or "The Fortress". It was declared by UNESCO as a World Heritage Site, together with the other historical monuments of the Ciudad Colonial.

Wikipedia: Fortaleza Ozama (EN)